Anti-Rapsyn Monoclonal Antibody

Biomaterial Description

The anti-rapsyn monoclonal antibody (clone 1234) is a high-affinity antibody developed to specifically recognize rapsyn (43K protein), a peripheral membrane protein critical for clustering acetylcholine receptors at the neuromuscular junction. It was generated through immunization against purified 43K protein isolated from Torpedo postsynaptic membranes and has been validated to detect both monomeric and oligomeric forms of rapsyn under native and denaturing conditions. The antibody provides robust and reproducible labeling in immunoblotting, immunoprecipitation, and immunofluorescence assays, enabling precise visualization of rapsyn’s interactions with postsynaptic components. By supporting high-resolution mapping of synaptic protein organization, this biomaterial offers a reliable tool for advancing studies of receptor clustering and postsynaptic membrane architecture.

Applications

-Synapse biology research: Track rapsyn localization and clustering in neuromuscular junctions.

-Mechanistic studies: Investigate rapsyn’s role in acetylcholine receptor stabilization and postsynaptic membrane assembly.

-Disease modeling: Characterize rapsyn dysfunction in congenital myasthenic syndromes and other neuromuscular disorders.

-Drug discovery: Screen compounds that modulate receptor clustering or synaptic protein interactions.

Advantages

-Specificity: Selectively binds rapsyn without cross-reactivity to acetylcholine receptor subunits or other postsynaptic proteins.

-Versatility: Effective across multiple assay formats (Western blot, immunoprecipitation, immunofluorescence).

-Research impact: Facilitates high-resolution mapping of synaptic protein interactions, advancing understanding of neuromuscular junction biology.

Distributor Information

Non-Exclusive License available.