Anti-TSLP Receptor Antibody (Clone 22H9)

Biomaterial Description

This rat monoclonal antibody, Clone 22H9, specifically targets the extracellular domain of the murine thymic stromal lymphopoietin receptor (TSLPR/CRLF2). This antibody enables precise detection of TSLPR on hematopoietic and lymphoid cells and is optimized for flow cytometry applications. By targeting a key component of the TSLP signaling axis, Clone 22H9 supports investigation into cytokine-mediated immune regulation, including pathways involving Stat5 activation and cell proliferation.

Applications

-Flow cytometric profiling of TSLPR expression in murine immune cell populations

-Characterization of CRLF2-positive cells in models of allergy, inflammation, and hematopoiesis

-Mechanistic studies of TSLP signaling and receptor-ligand interactions

-Evaluation of cytokine receptor dynamics in genetically modified mouse strains

Advantages

-High-affinity binding to the extracellular domain of murine TSLPR

-Validated for flow cytometry in bone marrow and lymphoid tissues

-Compatible with C57BL/6 and other common mouse strains

-Available in unconjugated and APC-conjugated formats

-Supports studies of Stat5 activation and noncanonical cytokine signaling

Distributor Information

Non-Exclusive License available.