IL-4 Transgenic Mouse Model for Human Bone and Immune Disorders

Biomaterial Description

This transgenic mouse model is engineered to overexpress Interleukin-4 (IL-4) in specific tissues, enabling researchers to study the dual role of IL-4 in immune modulation and bone metabolism. The model exhibits:

-Altered thymocyte development due to localized IL-4 expression in the thymus.

-Osteoporotic phenotypes resulting from systemic IL-4 overproduction, including reduced bone density and impaired osteoblast function.

This model is ideal for dissecting the molecular and cellular mechanisms underlying immune-bone interactions, particularly in diseases where IL-4 dysregulation is implicated.

Applications

-Bone disease research: Study of IL-4–induced osteoporosis and bone remodeling.

-Immunology: Investigation of thymocyte development and T-cell lineage commitment.

-Autoimmune and inflammatory disorders: Modeling diseases with IL-4–mediated immune dysregulation.

-Drug development: Preclinical testing of IL-4–targeted therapies for bone and immune conditions.

Advantages

-Dual phenotype: Simultaneous modeling of immune and skeletal pathologies.

-Mechanistic insight: Enables study of IL-4’s role in osteoclast/osteoblast balance and thymocyte maturation.

-Therapeutic testing: Suitable for evaluating IL-4 inhibitors or bone anabolic agents.

Distributor Information

Non-Exclusive License available.

Shipped from JAX:

JAX Stock #002230