Mouse monoclonal antibody to DCAL-1
Biomaterial – Antibody
Biomaterial Description
Researchers in Prof. Edward Clark’s laboratory have developed a monoclonal antibody to DCAL-1 (clone UW50) that has been successfully used in flow cytometry analyses. The anti-DCAL-1 monoclonal antibody (mouse IgM isotype) was purified from hybridoma cell culture. C-type lectin molecules play a crucial role in pathogen recognition and antigen uptake by immature dendritic cells and mediate the immune response of mature dendritic cells. DCAL-1 is a transmembrane, C-type lectin-like protein involved in the regulation of dendritic cells during the immune response. DCAL-1 is expressed in dendritic cells and B cells but not in T cells and monocytes.
Applications
Research Tool
Flow Cytometry
Western Blot
Advantages
Recognizes human DCAL-1
Incubation of anti-DCAL-1 monoclonal antibody with immature dendritic cells results in a partially mature dendritic cell phenotype that may have an important immunoregulatory role
Distributor Information
Non-Exclusive License available.
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swap_vertical_circlemode_editAuthors (1)Edward Clark
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swap_vertical_circlelibrary_booksReferences (2)
- Ryan, E. J., Marshall, A. J., Magaletti, D., Floyd, H., Draves, K. E., Olson, N. E., Clark, E. A. (2002), Dendritic Cell-Associated Lectin-1: A Novel Dendritic Cell-Associated, C-Type Lectin-Like Molecule Enhances T Cell Secretion of IL-4, The Journal of Immunology, 169, 5638-5648
- Ryan, E. J., Magaletti, D., Draves, K. E., Clark, E. A. (2008), Ligation of dendritic cell-associated lectin-1 induces partial maturation of human monocyte derived dendritic cells, Human Immunology, 70, 1-5
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swap_vertical_circlecloud_downloadSupporting documents (1)Product brochureMouse monoclonal antibody to DCAL-1.pdf