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Mouse monoclonal antibody to DCAL-1

Biomaterial – Antibody
Technology No. INV 42910
Biomaterial Description

Researchers in Prof. Edward Clark’s laboratory have developed a monoclonal antibody to DCAL-1 (clone UW50) that has been successfully used in flow cytometry analyses. The anti-DCAL-1 monoclonal antibody (mouse IgM isotype) was purified from hybridoma cell culture. C-type lectin molecules play a crucial role in pathogen recognition and antigen uptake by immature dendritic cells and mediate the immune response of mature dendritic cells. DCAL-1 is a transmembrane, C-type lectin-like protein involved in the regulation of dendritic cells during the immune response. DCAL-1 is expressed in dendritic cells and B cells but not in T cells and monocytes.

Applications

Research Tool

Flow Cytometry

Western Blot

Advantages

Recognizes human DCAL-1

Incubation of anti-DCAL-1 monoclonal antibody with immature dendritic cells results in a partially mature dendritic cell phenotype that may have an important immunoregulatory role

Distributor Information

Non-Exclusive License available.

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