Anti-Syntrophin Monoclonal Antibody

Biomaterial Description

The murine anti‑syntrophin monoclonal antibody (clone 1351) detects syntrophin proteins within the dystrophin complex. This antibody provides researchers and translational partners with a powerful tool to study the molecular architecture of neuromuscular junctions and muscle membranes. It is validated for immunohistochemistry, immunoblotting, and immunoprecipitation.

Syntrophins are a family of modular adapter proteins that recruit signaling molecules to the dystrophin complex. Each isoform (α1, β1, β2) contains specialized domains that bind enzymes and receptors, such as neuronal nitric oxide synthase, thereby enabling localized signaling at postsynaptic and muscle membrane sites.

Dystrophin is a large cytoskeletal protein that anchors the actin cytoskeleton to the extracellular matrix through the dystrophin‑associated glycoprotein complex. This structural linkage stabilizes muscle fibers during contraction and preserves the integrity of neuromuscular junctions. Loss of dystrophin function underlies muscular dystrophies, making its associated proteins critical targets for both basic research and therapeutic development.

By targeting conserved epitopes across syntrophin isoforms, the anti‑syntrophin monoclonal antibody enables precise mapping of syntrophin distribution and their differential association with dystrophin or utrophin complexes. This antibody supports investigations into receptor anchoring, synaptic signaling, and muscle disease mechanisms.

Applications

-Neuromuscular Junction Research: Map syntrophin distribution at AChR-rich postsynaptic sites.

-Muscle Disease Studies: Investigate syntrophin involvement in dystrophinopathies such as Duchenne muscular dystrophy.

-Synaptic Biology: Explore roles of syntrophins in synaptogenesis, receptor clustering, and signaling pathways.

-Protein Complex Characterization: Define isoform-specific associations within dystrophin and utrophin complexes.

-Therapeutic Development: Support drug discovery targeting dystrophin-associated signaling and stabilization mechanisms.

Advantages

-Isoform-Specific Detection: Differentiates α1-, β1-, and β2-syntrophin associations with dystrophin complexes.

-Validated Across Assays: Effective in immunohistochemistry, immunoblotting, and co-localization studies.

Distributor Information

Non-Exclusive License available.