BDCA2 Transgenic Mice
Biomaterial – Mouse
Biomaterial Description
Researchers in Prof. Edward Clark’s laboratory have developed a B6-BDCA2 transgenic mouse model that expresses human BDCA2 on plasmacytoid dendritic cells (pDCs). The BDCA2 mice are a useful tool for testing the role of BDCA2 in vivo. This unique model enables precise targeting of antigens to pDCs, facilitating advanced studies in immunologic tolerance and immune response modulation.
Applications
Autoimmune Disease Research: Utilize BDCA2 Transgenic Mice to explore mechanisms of immunologic tolerance and develop potential therapies for autoimmune conditions.
Vaccine Development: Investigate the role of pDCs in vaccine efficacy and design strategies to enhance immune responses through targeted antigen delivery.
Advantages
Specificity: The BDCA2 Transgenic Mice express human BDCA2 exclusively on pDCs, allowing for highly specific antigen targeting and immune response studies.
Distributor Information
Non-Exclusive License available.
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swap_vertical_circlemode_editAuthors (1)Edward Clark
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swap_vertical_circlelibrary_booksReferences (1)
- Chappell, C. P., Giltiay, N. V., Draves, K. E., Chen, C., Hayden-Ledbetter, M. S., Shlomchik, M. J., Kaplan, D. H., Clark, E. A. (2014), Targeting antigens through blood dendritic cell antigen 2 (BDCA2) on plasmacytoid dendritic cells promotes immunologic tolerance, The Journal of Immunology, 192, 5789-5801
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swap_vertical_circlecloud_downloadSupporting documents (1)Product brochureBDCA2 Transgenic Mice.pdf