A Machine Learning Algorithm for Predicting Colorectal Cancer Recurrence
The solution is a machine learning model to predict CRC recurrence and help with medical decision-making in a dynamic manner.
A Microfluidic Assay of Live Tissues for Personalized Medicine
This technology utilizes a microfluidic perfusion device and tumor tissue from cancer patients to predict a drug response at the time of diagnosis. This approach will guide the individual care for patients.
AI-triaged 3D Pathology
Innovations in medical imaging techniques more and more medical information to be gathered from a single biopsy sample, but pathologist review of such large datasets becomes prohibitively time intensive. This technology provides an AI-driven method for the triage of a 3D pathology dataset for review by a doctor, with areas of concern elevated to the doctor’s attention for review in order to detect disease faster and more accurately.
An RNA-Only, Positive Control Target for Clinical Diagnostic Testing
The technology is a robust control system that enables users to readily distinguish between DNA and RNA in bacteria.
Approaches to Address Missingness in Electronic Health Records
The solution is a machine learning model that accurately simulates recurrence in patients where frequent testing data is not available in their electronic health records.
Bile Detection Device for Intenstinal Obstruction and Methods of Use
Rotational abnormalities of the small bowel, known as Midgut volvulus, is a rare condition but left undiagnosed for over six hours may result in prolonged hospitalization, an intestinal transplant, or even fatal if undiagnosed. Biloccult is a reliable and rapid handheld device to detect the bile in vomit using an enclosed and encased testing strip. The first component of the device neutralizes the vomit and allows analytes to pass while the second component has antibodies that will bind to the analytes for detection.
Deep Learning Models for Automated Unbiased Measurement of Podocyte Foot Process Width
The solution is an automated foot process width estimation software that uses deep learning to automatically calculate the average podocyte foot process width and reduce the time it takes to assess kidney disease progression.
Enriched Nanopore Sequencing Using Real-Time Sequence Analysis
The solution is the combination of a Scalable Metagenomics Alignment Research Tool (SMART) with nanopore “Read Until” sequencing to create a point-of-service, real-time selective sequencing platform that can detect and identify pathogens or other DNA/RNA of interest.
High-Throughput Functional Genomics Tools to Assess Cell Migration
The solution is a method that enables massively parallel separation of cells based on their migratory capabilities, allowing for assessment of different types of cell migration including chemotaxis, chemokinesis, amoeboid 3D migration, and galvanotaxis.
Improving Efficiency of Auditory Brainstem Response Audiometry Using an Adaptive Procedure
The solution is an algorithm that uses an adaptive Bayesian procedure to optimize the stimulus frequency and level for determining hearing threshold from ABR to improve efficiency of ABR audiometry.
Microdissected “Cuboids” for Microfluidic Drug Testing of Intact Tissues
This device uses a motorized tissue slicer to dissect tissue pieces into sub-millimeter-size cuboidal shapes for screening. This method allows for controlled delivery and testing of different reagents to reduce cytotoxicity testing.
Structure from Motion Reconstruction of Laryngotracheal Surfaces
The solution is the use of an image processing technique, called structure from motion (SfM), to reconstruct 3D surface renderings of the pediatric larynx and trachea from clinical endoscopy videos.
Synthetic Genetic Platform in Yeast and Methods of Use
This technology offers engineered signaling of the auxin response from the plant Arabidopsis into yeast called AuxInYeast. This device can rapidly quantify auxin and the impact of a given sequence on transcription where inventors can “humanize” the circuit. AuxInYeast can mitigate the slow and high throughput of small molecule testing for drug candidates.
Syphilis Diagnostic Assay by Loop-Mediated Isothermal Amplification
The solution is a rapid assay that targets nucleic acids of the causative organism of syphilis, Treponema pallidum, to diagnose syphilis quickly and accurately.
System and Method for Ranking Bacterial Activity Leading to Tooth and Gum Disease
This technology optically measures pH to detect bacterial infections that cause tooth and gum diseases. The system emits an excitation light at the teeth of a patient and uses a detector to measure the light and process the yields with machine learning for early-stage enamel demineralization.
Treponema Pallidum-Specific Aptamers for Syphilis Diagnostics
The solution is the development of Treponema pallidum-specific aptamers to be used in accurate point-of-care diagnostic assays for syphilis.
Utilizing Variant Transcripts of PSEN2 for Diagnosis and Treatment of Tauopathies
The solution is an alternatively spliced exon in PSEN2 that leads to an aberrant protein product, providing a potential target for therapeutic intervention for sporadic Alzheimer’s Disease.