A Method to Direct the Differentiation of Human Induced Pluripotent Stem Cells into Ameloblasts and Odontoblasts
These present technologies offer a foundation for the development of periodontal regenerative therapies and further study of periodontal diseases affecting enamel and dentin formation.
Approaches to Improving Cardiac Regeneration
The innovation offers insights into cardiomyocyte proliferation which may have important implications for therapeutic strategies that target cardiac regeneration in treating inherited and acquired heart diseases.
Bikunin Biomimetic with Anti-Inflammatory and Antiviral Activity
The solution is a serine protease inhibitor, bikunin, that plays a role in controlling the early immune response to Influenza A virus.
Carbon-11 PET Radiotracer for Alpha1A Adrenoceptors
The solution is a novel carbon-11 radiotracer that binds selectively to alpha1A adrenoceptor and can be visualized through positron emission tomography imaging.
Cell Barcoding for Multiplexed Pooled Screening of Perturbations in Cells
The solution is a novel pooled screening approach, called CellCode, that utilizes lentiviral barcoded libraries to encode perturbation histories in cells that are then decoded in downstream assays.
Constitutively Active RIP Kinases/Caspases
The disclosed technology offers recombinant programmed cell death enzymes that can constitutively trigger apoptosis, pyroptosis or necroptosis. These novel proteins have the potential to cause rapid cell death in diseased cells and are available for immediate generation of IND-enabling data.
De Novo Designed Protein Binders Targeting TGFβRII, CTLA4, and PD-L1
Novel protein minibinders which bind to convex protein target sites on TGFβRII, CTLA4, and PD-L1 with high affinity and potent biological activity are the solution.
Deep Learning Approaches for Protein Scaffolding
This technology uses advanced deep learning methods to design proteins with specific functional sites, offering a novel approach to protein design that is both efficient and versatile.
Glycosylated Nanoparticles for Vaccines
The solution is a method to engineer glycoproteins onto the surface of protein nanoparticle vaccine scaffolds to enhance vaccine-elicited immune responses.
High-Throughput Drug Screening of Cancer Stem Cells
This invention discloses methods for designing a personalized therapeutic regimen for patients with AML based on an individual's unique drug sensitivities. The methods offer clinical utility beyond the scope of standard diagnostics and assays and allow clinicians to tailor treatments based on a patient’s cancer stem cell chemosensitivity.
High-Throughput Drug Screens on a 3D Tumor-on-a-Chip to Monitor Cancer Cell Viability and Migration
The solution is a three-dimensional human renal cell carcinoma (RCC)-on-a-chip for screening drugs that could be developed as anti-metastasis agents.
Homo-Oligomeric Protein Assemblies
The solution is a novel approach to design polypeptides that form cyclic homo-oligomers, offering potential applications in various fields.
IgG3 Spike Protein Binding Assay
The innovation offers a fast, inexpensive single-tier assay that offers clinical utility as a screening method to identify patients who have SARS-CoV-2 immunity based on the presence of spike-binding, neutralizing IgG3 antibodies against SARS-CoV-2
Increasing In Vivo Success of Stem Cells with GSK3 Inhibition
The disclosed innovation provides methods for increasing populations of hematopoietic, mesenchymal, mesodermal, or neural progenitor/ stem cells in vivo in a mammalian subject.
Injectable Recombinant Protein-Based Hydrogels for Therapeutic Delivery
The solution is a self-healing protein-based hydrogel that supports minimally invasive cell delivery through catheter injection.
Kidney Organoid Models as Research Tools
The collection of technologies offers a variety of hPSC-derived kidney organoid models that accurately recapitulate kidney function and disease. The robust platform is ready for immediate use in high-growth research areas such as kidney tissue regeneration studies, drug candidate screening, and renal pathophysiology research.
Metabolite Biomarkers for the Detection of Colorectal Cancer
The technologies offer a simple yet powerful method for identifying serum markers of disease in colon cancer from peripheral blood. These technologies offer high sensitivity and specificity as compared to standard diagnostic methods such as colonoscopy but offer additional utility as they require no in-office clinical procedure. Together, they offer a promising new diagnostic and monitoring tool to support clinical decision making in colon cancer.
Method for Quantification of Lipoprotein(a)
The innovation offers a reference method for the quantification of lipoprotein(a) in clinical and research applications and serves to broaden the use of Lp(a) as a biomarker in cardiovascular disease outcome measurement and risk assessment.
Minibinder-Drug Conjugates Targeting Human EpCAM and PDL1 Receptors for Targeted Cancer Therapy
This technology offers a set of novel polypeptides designed to bind to human EpCAM and PDL1 receptors, offering potential applications in treating cancer, autoimmune diseases, and inflammation.
Modulating Prime Editing Efficiency Through Epigenetic Reprogramming
The innovation is a method that involves reprogramming the epigenetic environment in the vicinity of a target site to modulate prime editing efficiency.
Nanoactuators Based FePd Nanohelices to Initiate Cell Apoptosis
This technology offers a nan-actuator to initiate apoptosis and the removal of cancer cells. The nano-actuators magnetically is propelled to target cells and oscillate for mechanical damage of the cells.
Omega Muricholic Acid: A Novel PXR Ligand to Treat Hepato-Intestinal Diseases
The innovation offers a novel, murine-specific bile acid known as omega muricholic acid (wMCA). The technology has shown to be a promicing new avenue for the clinical management of inflammatory bowel disease (IBD).
Repurposing Combinations of Approved Drugs for Viral Outbreak Response and Readiness
The collection of technologies offers a simple yet powerful method for identifying combinations of previously FDA approved drugs with synergistic activity against viral infections. The technology is available for immediate use in preparation IND-enabling studies in high impact viral disease areas.
Small Molecule Inhibitors for the Treatment of Epilepsy
The solution is a potential new therapeutic target related to inhibition of specific regulators of the WNT pathway that can prevent and/or treat epilepsy.
Systems and Methods for Deep Brain Stimulation Using Kinematic Feedback for Treatment of Movement Disorders
This technology offers the statistical analysis of gait parameters, a motor symptom of Parkinson’s disease. This system conducts deep brain stimulation and adapts its response with the stimulation frequency varying between low (i.e. 60 Hz) and high (>130 Hz) frequencies to improve gait.
Targeted Protein Degradation in Bacteria Contributes to Antibiotic Efficacy
The solution is a method to develop new antibiotic proteolysis targeting chimeras (PROTACs) that target proteins of interest for degradation in bacteria to counteract antibiotic resistance.
Targeting von Willebrand Factor to Model Disease in Human Pluripotent Stem Cells
The disclosed technology offers a CRISPR-Cas9 generated, isogenic hPSC-EC in-vitro model for studying disease dynamics and therapeutic candidates for VWF-deficient diseases such as Von Willebrand disease (VWD).
TERIS
Treating Mitochondrial Dysfunction in Heart Failure
This technology targets the root cause of heart failure by employing nicotinamide riboside (NR) to protect mitochondrial function and reduce inflammation, and normalizing MRPP2 levels to improve mitochondrial DNA processing, offering a potential avenue to reverse the course of heart failure.
Treponema Pallidum-Specific Aptamers for Syphilis Diagnostics
The solution is the development of Treponema pallidum-specific aptamers to be used in accurate point-of-care diagnostic assays for syphilis.
Utilizing Variant Transcripts of PSEN2 for Diagnosis and Treatment of Tauopathies
The solution is an alternatively spliced exon in PSEN2 that leads to an aberrant protein product, providing a potential target for therapeutic intervention for sporadic Alzheimer’s Disease.