A Method to Direct the Differentiation of Human Induced Pluripotent Stem Cells into Ameloblasts and Odontoblasts

These present technologies offer a foundation for the development of periodontal regenerative therapies and further study of periodontal diseases affecting enamel and dentin formation.

Antibody-Based Inhibition of Uropathogenic E. coli Adhesion

The technology offers innovative antibody compositions that target the FimH adhesin of uropathogenic E. coli, preventing bacterial adhesion and biofilm formation.

Bikunin Biomimetic with Anti-Inflammatory and Antiviral Activity

The solution is a serine protease inhibitor, bikunin, that plays a role in controlling the early immune response to Influenza A virus.

Carbon-11 PET Radiotracer for Alpha1A Adrenoceptors

The solution is a novel carbon-11 radiotracer that binds selectively to alpha1A adrenoceptor and can be visualized through positron emission tomography imaging.

CD36-Binding Aptamers for Targeted Drug Delivery

This technology offers CD36-binding aptamers with various potential applications, including the isolation or depletion of monocytes or macrophages, targeting platelets, and delivering drugs specifically to sites of inflammation or injury.

CD62L (L-Selectin) Aptamer for T Cell Isolation

A novel aptamer technology designed to isolate naïve and memory T cells by targeting the CD62L (L-Selectin) marker, facilitating applications in diagnostics, therapeutics, and research. The aptamer can also be used to detect soluble CD62L, a potential diagnostic marker for various diseases.

Cell Barcoding for Multiplexed Pooled Screening of Perturbations in Cells

The solution is a novel pooled screening approach, called CellCode, that utilizes lentiviral barcoded libraries to encode perturbation histories in cells that are then decoded in downstream assays.

Constitutively Active cGAS for Enhanced Immune Response

This technology involves the design of constitutively active cyclic GMP-AMP synthase (cGAS) mutants that stimulate a robust immune response without the need for DNA binding.

Custom Transmembrane β-Barrel Proteins

This technology involves the design of eight-stranded transmembrane β-barrel proteins (TMBs) with no homology to known TMBs, offering potential for a wide range of synthetic biology applications.

Cyborg Chimeric Antigen Receptor (CAR) T Cells for Targeted Cancer Immunotherapies

This technology involves the in situ bioconjugation of synthetic peptides onto universal chimeric antigen receptor (CAR) T cells, enhancing their ability to target and destroy cancer cells.

Cytosolic Delivery of Biologics

Innovative noncovalent tags enable efficient delivery of macrobiomolecules, such as siRNA and proteins, directly into the cytosol, bypassing traditional endocytic pathways.

Deep Learning Approaches for Protein Scaffolding

This technology uses advanced deep learning methods to design proteins with specific functional sites, offering a novel approach to protein design that is both efficient and versatile.

Device and Method to Non-invasively Treat Urinary Stones in Pets

A novel ultrasound-guided technology designed to noninvasively fragment urinary stones in pets, reducing the need for invasive surgery.

Diagnostics for Autoimmune Diseases

The technology offers a diagnostic kit that uses existing antibodies targeting innovative biomarkers for detecting immune complexes, neutrophil extracellular traps (NETs), and FcgRIIA shedding, which are involved in immune complex-driven inflammation. This innovation offers new insights for diagnosing, prognosticating, and treating autoimmune diseases.

Endosome Escape-Enabling Polymer Micelles for Targeted Delivery of Nucleic Acids and Peptides

Innovative pH-sensitive polymer micelles and membrane-lytic peptides enhance the intracellular delivery and efficacy of therapeutic agents through enabling endosome escape.

Enhanced Detection of Eicosanoids and Carboxylic Acids by Mass Spectrometry

Innovative reagent and method for improving the sensitivity and accuracy of detecting eicosanoids and carboxylic acids using mass spectrometry.

Glycosylated Nanoparticles for Vaccines

The solution is a method to engineer glycoproteins onto the surface of protein nanoparticle vaccine scaffolds to enhance vaccine-elicited immune responses.

High-Throughput Drug Screens on a 3D Tumor-on-a-Chip to Monitor Cancer Cell Viability and Migration

The solution is a three-dimensional human renal cell carcinoma (RCC)-on-a-chip for screening drugs that could be developed as anti-metastasis agents.

Homo-Oligomeric Protein Assemblies

The solution is a novel approach to design polypeptides that form cyclic homo-oligomers, offering potential applications in various fields.

Injectable Recombinant Protein-Based Hydrogels for Therapeutic Delivery

The solution is a self-healing protein-based hydrogel that supports minimally invasive cell delivery through catheter injection.

Integrin α4β1-Specific DNA Aptamer Conjugates

A novel DNA aptamer-polymer conjugate designed to selectively bind integrin α4β1 (VLA-4), offering potential treatments for T-cell based autoimmune disorders and T-cell malignancies.

MEK Inhibition for Treating Darier Disease and Skin Fragility Disorders

A novel therapeutic approach utilizing MEK inhibitors to treat Darier disease and other skin fragility disorders by targeting the underlying molecular pathways.

Metabolite Biomarkers for the Detection of Colorectal Cancer

The technologies offer a simple yet powerful method for identifying serum markers of disease in colon cancer from peripheral blood. These technologies offer high sensitivity and specificity as compared to standard diagnostic methods such as colonoscopy but offer additional utility as they require no in-office clinical procedure. Together, they offer a promising new diagnostic and monitoring tool to support clinical decision making in colon cancer.

Method for Quantification of Lipoprotein(a)

The innovation offers a reference method for the quantification of lipoprotein(a) in clinical and research applications and serves to broaden the use of Lp(a) as a biomarker in cardiovascular disease outcome measurement and risk assessment.

Mixed Chirality Peptide Macrocycles with Internal Symmetry

This technology leverages computational design to create mixed chirality peptide macrocycles with internal symmetry, offering a new avenue for therapeutic and nanomaterial design.

Modulating Prime Editing Efficiency Through Epigenetic Reprogramming

The innovation is a method that involves reprogramming the epigenetic environment in the vicinity of a target site to modulate prime editing efficiency.

Multi-Functional Mucosal Vaccine Platform for Enhanced Immunogenicity

A novel mucosal vaccine platform designed to improve mucosal immune responses against infectious diseases through targeted delivery and prolonged stability.

Nanoactuators Based FePd Nanohelices to Initiate Cell Apoptosis

This technology offers a nano-actuator to initiate apoptosis and the removal of cancer cells. The nano-actuators are magnetically propelled to target cells and then oscillate, causing mechanical damage to the cells.

Novel Nanoparticle Immunogens for Influenza Vaccines

This technology offers a new approach to influenza vaccines using computationally designed nanoparticle immunogens that elicit potent, neutralizing antibodies against influenza viruses.

Polymer-Based Nanoplatform for mRNA Delivery to Cancer Cells and Stem Cells

A novel nanoparticle system designed for efficient mRNA delivery to various cancer cell types and human induced pluripotent stem cells.

Protective Monoclonal Antibodies for Reducing Pseudomonas aeruginosa Burden

High-affinity monoclonal antibodies derived from cystic fibrosis patients' B cells show potent activity against Pseudomonas aeruginosa, offering a promising treatment for vulnerable patients.

Protein Homodimers with Tunable Symmetric Pockets: A Novel Approach to Binding Symmetric Molecules

This technology offers de novo designed protein homodimers with tunable symmetric pockets, enabling the binding of symmetric molecules for diverse applications.

Repurposing Combinations of Approved Drugs for Viral Outbreak Response and Readiness

The collection of technologies offers a simple yet powerful method for identifying combinations of previously FDA approved drugs with synergistic activity against viral infections. The technology is available for immediate use in preparation IND-enabling studies in high impact viral disease areas.

Secretion-Optimized Protein Nanoparticles for Eukaryotic Expression and Genetic Delivery

This technology offers innovative protein nanoparticles designed for efficient secretion in eukaryotic cells, enhancing genetic delivery and therapeutic applications.

Small Molecule Analgesic AS1 for Alleviating Pain

AS1 is a novel small molecule that changes how we perceive pain, making painful experiences less unpleasant and reducing the discomfort associated with them. It reverses the negative hedonic valence of painful stimuli, alleviating pain and reducing aversion of negative stimuli associated with pain.

Small Molecule Inhibitors for the Treatment of Epilepsy

The solution is a potential new therapeutic target related to inhibition of specific regulators of the WNT pathway that can prevent and/or treat epilepsy.

Systems and Methods for Deep Brain Stimulation Using Kinematic Feedback for Treatment of Movement Disorders

This technology offers the statistical analysis of gait parameters, a motor symptom of Parkinson’s disease. This system conducts deep brain stimulation and adapts its response with the stimulation frequency varying between low (i.e. 60 Hz) and high (>130 Hz) frequencies to improve gait.

Targeted Protein Degradation in Bacteria Contributes to Antibiotic Efficacy

The solution is a method to develop new antibiotic proteolysis targeting chimeras (PROTACs) that target proteins of interest for degradation in bacteria to counteract antibiotic resistance.

Targeting von Willebrand Factor to Model Disease in Human Pluripotent Stem Cells

The disclosed technology offers a CRISPR-Cas9 generated, isogenic hPSC-EC in-vitro model for studying disease dynamics and therapeutic candidates for VWF-deficient diseases such as Von Willebrand disease (VWD).

TERIS

Transferrin Receptor-Binding Aptamers for Cancer Cell Depletion in Adoptive T-Cell Therapy

Innovative DNA aptamers that bind to the transferrin receptor (TfR1) offer a novel method for depleting cancer cells from therapeutic cell populations, enhancing the safety and efficacy of adoptive T-cell therapies. Additionally, these aptamers may be used for targeted delivery via the transferrin receptor.

Treating Mitochondrial Dysfunction in Heart Failure

This technology targets the root cause of heart failure by employing nicotinamide riboside (NR) to protect mitochondrial function and reduce inflammation, and normalizing MRPP2 levels to improve mitochondrial DNA processing, offering a potential avenue to reverse the course of heart failure.

Treponema Pallidum-Specific Aptamers for Syphilis Diagnostics

The solution is the development of Treponema pallidum-specific aptamers to be used in accurate point-of-care diagnostic assays for syphilis.

Utilizing Variant Transcripts of PSEN2 for Diagnosis and Treatment of Tauopathies

The solution is an alternatively spliced exon in PSEN2 that leads to an aberrant protein product, providing a potential target for therapeutic intervention for sporadic Alzheimer’s Disease.