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A Method to Direct the Differentiation of Human Induced Pluripotent Stem Cells into Ameloblasts and Odontoblasts

These present technologies offer a foundation for the development of periodontal regenerative therapies and further study of periodontal diseases affecting enamel and dentin formation.

TBD
Cell Barcoding for Multiplexed Pooled Screening of Perturbations in Cells

The solution is a novel pooled screening approach, called CellCode, that utilizes lentiviral barcoded libraries to encode perturbation histories in cells that are then decoded in downstream assays.

TBD
De Novo Designed Protein Binders Targeting TGFβRII, CTLA4, and PD-L1

Novel protein minibinders which bind to convex protein target sites on TGFβRII, CTLA4, and PD-L1 with high affinity and potent biological activity are the solution.

TBD
Deep Learning Approaches for Protein Scaffolding

This technology uses advanced deep learning methods to design proteins with specific functional sites, offering a novel approach to protein design that is both efficient and versatile.

TBD
Glycosylated Nanoparticles for Vaccines

The solution is a method to engineer glycoproteins onto the surface of protein nanoparticle vaccine scaffolds to enhance vaccine-elicited immune responses.

TBD
High-Throughput Drug Screening of Cancer Stem Cells

This invention discloses methods for designing a personalized therapeutic regimen for patients with AML based on an individual's unique drug sensitivities. The methods offer clinical utility beyond the scope of standard diagnostics and assays and allow clinicians to tailor treatments based on a patient’s cancer stem cell chemosensitivity.

TBD
High-Throughput Drug Screens on a 3D Tumor-on-a-Chip to Monitor Cancer Cell Viability and Migration

The solution is a three-dimensional human renal cell carcinoma (RCC)-on-a-chip for screening drugs that could be developed as anti-metastasis agents.

TBD
Increasing In Vivo Success of Stem Cells with GSK3 Inhibition

The disclosed innovation provides methods for increasing populations of hematopoietic, mesenchymal, mesodermal, or neural progenitor/ stem cells in vivo in a mammalian subject.

TBD
Injectable Recombinant Protein-Based Hydrogels for Therapeutic Delivery

The solution is a self-healing protein-based hydrogel that supports minimally invasive cell delivery through catheter injection.

TBD
Metabolite Biomarkers for the Detection of Colorectal Cancer

The technologies offer a simple yet powerful method for identifying serum markers of disease in colon cancer from peripheral blood. These technologies offer high sensitivity and specificity as compared to standard diagnostic methods such as colonoscopy but offer additional utility as they require no in-office clinical procedure. Together, they offer a promising new diagnostic and monitoring tool to support clinical decision making in colon cancer.

TBD
Mixed Chirality Peptide Macrocycles with Internal Symmetry

This technology leverages computational design to create mixed chirality peptide macrocycles with internal symmetry, offering a new avenue for therapeutic and nanomaterial design.

TBD
Omega Muricholic Acid: A Novel PXR Ligand to Treat Hepato-Intestinal Diseases

The innovation offers a novel, murine-specific bile acid known as omega muricholic acid (wMCA). The technology has shown to be a promicing new avenue for the clinical management of inflammatory bowel disease (IBD).

TBD
Repurposing Combinations of Approved Drugs for Viral Outbreak Response and Readiness

The collection of technologies offers a simple yet powerful method for identifying combinations of previously FDA approved drugs with synergistic activity against viral infections. The technology is available for immediate use in preparation IND-enabling studies in high impact viral disease areas.

TBD
Transmembrane Protein Pores

This technology offers the computational design of protein pores that can selectively conduct ions and enable the passage of small-molecule fluorophores, offering a new approach to creating transmembrane channels with potential applications in biotechnology and medicine.

TBD
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