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A Microfluidic Assay of Live Tissues for Personalized Medicine

This technology utilizes a microfluidic perfusion device and tumor tissue from cancer patients to predict a drug response at the time of diagnosis. This approach will guide the individual care for patients.

TBD
AI-triaged 3D Pathology

Innovations in medical imaging techniques more and more medical information to be gathered from a single biopsy sample, but pathologist review of such large datasets becomes prohibitively time intensive. This technology provides an AI-driven method for the triage of a 3D pathology dataset for review by a doctor, with areas of concern elevated to the doctor’s attention for review in order to detect disease faster and more accurately.

TBD
An RNA-Only, Positive Control Target for Clinical Diagnostic Testing

The technology is a robust control system that enables users to readily distinguish between DNA and RNA in bacteria.

TBD
Bile Detection Device for Intenstinal Obstruction and Methods of Use

Rotational abnormalities of the small bowel, known as Midgut volvulus, is a rare condition but left undiagnosed for over six hours may result in prolonged hospitalization, an intestinal transplant, or even fatal if undiagnosed. Biloccult is a reliable and rapid handheld device to detect the bile in vomit using an enclosed and encased testing strip. The first component of the device neutralizes the vomit and allows analytes to pass while the second component has antibodies that will bind to the analytes for detection.

TBD
Deep Learning Models for Automated Unbiased Measurement of Podocyte Foot Process Width

The solution is an automated foot process width estimation software that uses deep learning to automatically calculate the average podocyte foot process width and reduce the time it takes to assess kidney disease progression.

TBD
Enriched Nanopore Sequencing Using Real-Time Sequence Analysis

The solution is the combination of a Scalable Metagenomics Alignment Research Tool (SMART) with nanopore “Read Until” sequencing to create a point-of-service, real-time selective sequencing platform that can detect and identify pathogens or other DNA/RNA of interest.

TBD
High-Throughput Functional Genomics Tools to Assess Cell Migration

The solution is a method that enables massively parallel separation of cells based on their migratory capabilities, allowing for assessment of different types of cell migration including chemotaxis, chemokinesis, amoeboid 3D migration, and galvanotaxis.

TBD
Improving Efficiency of Auditory Brainstem Response Audiometry Using an Adaptive Procedure

The solution is an algorithm that uses an adaptive Bayesian procedure to optimize the stimulus frequency and level for determining hearing threshold from ABR to improve efficiency of ABR audiometry.

TBD
Microdissected “Cuboids” for Microfluidic Drug Testing of Intact Tissues

This device uses a motorized tissue slicer to dissect tissue pieces into sub-millimeter-size cuboidal shapes for screening. This method allows for controlled delivery and testing of different reagents to reduce cytotoxicity testing.

TBD
Structure from Motion Reconstruction of Laryngotracheal Surfaces

The solution is the use of an image processing technique, called structure from motion (SfM), to reconstruct 3D surface renderings of the pediatric larynx and trachea from clinical endoscopy videos.

TBD
Synthetic Genetic Platform in Yeast and Methods of Use

This technology offers engineered signaling of the auxin response from the plant Arabidopsis into yeast called AuxInYeast. This device can rapidly quantify auxin and the impact of a given sequence on transcription where inventors can “humanize” the circuit. AuxInYeast can mitigate the slow and high throughput of small molecule testing for drug candidates.

TBD
Syphilis Diagnostic Assay by Loop-Mediated Isothermal Amplification

The solution is a rapid assay that targets nucleic acids of the causative organism of syphilis, Treponema pallidum, to diagnose syphilis quickly and accurately.

TBD
System and Method for Ranking Bacterial Activity Leading to Tooth and Gum Disease

This technology optically measures pH to detect bacterial infections that cause tooth and gum diseases. The system emits an excitation light at the teeth of a patient and uses a detector to measure the light and process the yields with machine learning for early-stage enamel demineralization.

TBD
Treponema Pallidum-Specific Aptamers for Syphilis Diagnostics

The solution is the development of Treponema pallidum-specific aptamers to be used in accurate point-of-care diagnostic assays for syphilis.

TBD
Utilizing Variant Transcripts of PSEN2 for Diagnosis and Treatment of Tauopathies

The solution is an alternatively spliced exon in PSEN2 that leads to an aberrant protein product, providing a potential target for therapeutic intervention for sporadic Alzheimer’s Disease.

TBD
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