A Method to Direct the Differentiation of Human Induced Pluripotent Stem Cells into Ameloblasts and Odontoblasts

These present technologies offer a foundation for the development of periodontal regenerative therapies and further study of periodontal diseases affecting enamel and dentin formation.

Advanced Tools for Molecular Profiling and RNA Interaction Analysis

The solution is a set of innovative tools leveraging oligonucleotide-directed biolabeling for enhanced molecular profiling and RNA interaction analysis within their native cellular context.

Amyloidogenic Peptide Traps: A Novel Approach to Amyloid-Related Diseases

This technology is a novel method to design protein scaffolds to bind and neutralize amyloid-forming proteins, offering a potential therapeutic intervention for diseases associated with amyloid fibrils.

Axle-Rotor Protein Assemblies: A New Frontier in Protein Nanomachines

This technology offers the design of innovative protein nanomachines, featuring unique axle and rotor components. These assemblies have potential applications in various fields, including nanotechnology and biomedicine.

CADD Scores

Cell Barcoding for Multiplexed Pooled Screening of Perturbations in Cells

The solution is a novel pooled screening approach, called CellCode, that utilizes lentiviral barcoded libraries to encode perturbation histories in cells that are then decoded in downstream assays.

Clinical Assessment of Music Perception for Cochlear Implants (CAMP)

Combinatorial Barcoding for Protein Identification

This technology is a novel method for protein identification using combinatorial barcoding, offering a unique approach to analyze complex mixtures of proteins.

Constitutively Active RIP Kinases/Caspases

The disclosed technology offers recombinant programmed cell death enzymes that can constitutively trigger apoptosis, pyroptosis or necroptosis. These novel proteins have the potential to cause rapid cell death in diseased cells and are available for immediate generation of IND-enabling data.

Custom Transmembrane β-Barrel Proteins

This technology involves the design of eight-stranded transmembrane β-barrel proteins (TMBs) with no homology to known TMBs, offering potential for a wide range of synthetic biology applications.

De Novo Design of ABC Heterotrimeric Proteins

The technology is a novel method for designing ABC heterotrimeric proteins de novo, offering potential applications in biotechnology and medicine.

De Novo Designed Oligomeric Proteins that Modulate Fibroblast Growth Factor Signaling and Vascular Differentiation

The solution is a cyclic homo-oligomeric fibroblast growth factor (FGF) receptor binding module with tunable geometric properties that modulates activity of isoform-specific FGF signaling.

Deep Learning Approaches for Protein Scaffolding

This technology uses advanced deep learning methods to design proteins with specific functional sites, offering a novel approach to protein design that is both efficient and versatile.

Deep Learning Models for Automated Unbiased Measurement of Podocyte Foot Process Width

The solution is an automated foot process width estimation software that uses deep learning to automatically calculate the average podocyte foot process width and reduce the time it takes to assess kidney disease progression.

Design of Customizable Immunoglobulin-like Domains

This technology is a novel approach to design highly stable immunoglobulin-like domains, offering tailored structures with superior biophysical properties.

Di-Nitro Compound Internal Exchange Reporter for Mass Spectrometry

The innovation offers a collection of compounds that serve as internal exchange reporters (IERs) of exchange conditions with a superior ability to overcome challenges in reproducibility of Hydrogen/Deuterium exchange studies for the determination of protein structure.

EarlyEdU

Efficient Duplex Sequencing Using High Fidelity Next Generation Sequencing Reads

The innovation is a library preparation technique that produces an error-corrected nucleic acid library for sequencing.

Enriched Nanopore Sequencing Using Real-Time Sequence Analysis

The solution is the combination of a Scalable Metagenomics Alignment Research Tool (SMART) with nanopore “Read Until” sequencing to create a point-of-service, real-time selective sequencing platform that can detect and identify pathogens or other DNA/RNA of interest.

Enzymatic Synthesis of DNA Containing Non-Standard Nucleotide Basepairs

The solution is a strategy for enzymatic synthesis of double-stranded DNA oligonucleotides that contain modified natural bases and xenonucleobases, including up to 12 different nucleotides that form six orthogonal pairs.

Epar Bangla Opar Bangla: Bangla Across Borders!

FEFF

High-Throughput Drug Screening of Cancer Stem Cells

This invention discloses methods for designing a personalized therapeutic regimen for patients with AML based on an individual's unique drug sensitivities. The methods offer clinical utility beyond the scope of standard diagnostics and assays and allow clinicians to tailor treatments based on a patient’s cancer stem cell chemosensitivity.

High-Throughput Drug Screens on a 3D Tumor-on-a-Chip to Monitor Cancer Cell Viability and Migration

The solution is a three-dimensional human renal cell carcinoma (RCC)-on-a-chip for screening drugs that could be developed as anti-metastasis agents.

High-Throughput Functional Genomics Tools to Assess Cell Migration

The solution is a method that enables massively parallel separation of cells based on their migratory capabilities, allowing for assessment of different types of cell migration including chemotaxis, chemokinesis, amoeboid 3D migration, and galvanotaxis.

Homo-Oligomeric Protein Assemblies

The solution is a novel approach to design polypeptides that form cyclic homo-oligomers, offering potential applications in various fields.

IASystem™ Software

IgG3 Spike Protein Binding Assay

The innovation offers a fast, inexpensive single-tier assay that offers clinical utility as a screening method to identify patients who have SARS-CoV-2 immunity based on the presence of spike-binding, neutralizing IgG3 antibodies against SARS-CoV-2

Increasing In Vivo Success of Stem Cells with GSK3 Inhibition

The disclosed innovation provides methods for increasing populations of hematopoietic, mesenchymal, mesodermal, or neural progenitor/ stem cells in vivo in a mammalian subject.

Injectable Recombinant Protein-Based Hydrogels for Therapeutic Delivery

The solution is a self-healing protein-based hydrogel that supports minimally invasive cell delivery through catheter injection.

Massively Multiplexed Single-Cell Proteomics

This technology is a scalable and massively multiplexed single-cell proteomics approach that leverages combinatorial indexing by split-pooling. The innovation presented here is a novel peptide labeling strategy compatible with fixed, permeabilized cells using biorthogonal chemistry that will covalently attach chemical barcodes.

Metabolite Biomarkers for the Detection of Colorectal Cancer

The technologies offer a simple yet powerful method for identifying serum markers of disease in colon cancer from peripheral blood. These technologies offer high sensitivity and specificity as compared to standard diagnostic methods such as colonoscopy but offer additional utility as they require no in-office clinical procedure. Together, they offer a promising new diagnostic and monitoring tool to support clinical decision making in colon cancer.

Method for Quantification of Lipoprotein(a)

The innovation offers a reference method for the quantification of lipoprotein(a) in clinical and research applications and serves to broaden the use of Lp(a) as a biomarker in cardiovascular disease outcome measurement and risk assessment.

Modular Peptide Binding Proteins by Superhelical Matching

The solution is a universal method for de novo design of proteins made of repeating units that bind peptides with repeating sequences, with a one-to-one ratio of protein repeat units and peptide repeats.

Modular Repeat Protein Sculpting Using Rigid Helical Junctions

This technology enables the precise design of large proteins with diverse shapes using rigid helical junctions, facilitating the creation of stable and structurally unique protein assemblies.

Modulating Prime Editing Efficiency Through Epigenetic Reprogramming

The innovation is a method that involves reprogramming the epigenetic environment in the vicinity of a target site to modulate prime editing efficiency.

Multiplexed in situ Signal Amplification with Splint Ligation Extension Probes

This innovation describes Splint Ligation Extension (SLX) probes, which are ssDNA probe reagents with a known length and sequence, that can be used to augment RNA FISH, DNA FISH, and IF methods. SLX probes enable absolute quantification of target nucleic acid or protein abundance.

Musculoskeletal Atlas

Omega Muricholic Acid: A Novel PXR Ligand to Treat Hepato-Intestinal Diseases

The innovation offers a novel, murine-specific bile acid known as omega muricholic acid (wMCA). The technology has shown to be a promicing new avenue for the clinical management of inflammatory bowel disease (IBD).

Particle Positioning Device With Periodic Dielectric Structure

This technology offers a particle positioning device to trap and fix cell positions on MEMS resonators. The device uses a photonic crystal optical tweezers, MEMS, and microfluidic channels that decrease variable measurements.

Photopatterned Biomolecule Immobilization to Guide 3D Cell Fate in Natural Protein-Based Hydrogels

The technology is a method using photomediated oxime ligation to covalently decorate naturally derived hydrogels with bioactive proteins, such as growth factors, to spatially control encapsulated cell fate.

Photopatterning of Hydrogel Biomaterials

The solution is a generalizable and intuitive strategy using lasers to print 3D non-discrete patterns across cellular scales in biomaterials.

Phred, Phrap, Consed-Autofinish

PolyPhred

You will need to license Phred, Phrap, and Consed-Autofinish before obtaining PolyPhred.

PRIMUS

Programmable Genome Editing Using Molecular Proximity Sensors

The innovation is a strategy called P3 editing, which links protein-protein proximity to the formation of a functional CRISPR-Cas9 dual-component guide RNA.

Programmable Peptide-Based Metal-Organic Frameworks

This technology leverages structured symmetric cyclic peptides to create advanced metal-organic frameworks, offering enhanced stability and versatility.

Protein Homodimers with Tunable Symmetric Pockets: A Novel Approach to Binding Symmetric Molecules

This technology offers de novo designed protein homodimers with tunable symmetric pockets, enabling the binding of symmetric molecules for diverse applications.

Reconfigurable Asymmetric Protein Assemblies

This technology leverages the principles of implicit negative design to create reconfigurable asymmetric protein assemblies, offering a new paradigm in protein design.

Repurposing Combinations of Approved Drugs for Viral Outbreak Response and Readiness

The collection of technologies offers a simple yet powerful method for identifying combinations of previously FDA approved drugs with synergistic activity against viral infections. The technology is available for immediate use in preparation IND-enabling studies in high impact viral disease areas.

Spatial Multiplexing with Fluorescent “Rings”

The innovation is a highly multiplexed spatial imaging approach that only requires a single round of imaging. The cellular biomarkers are labeled using a distinct fluorescent signal pattern, a fluorescent “ring”, that is deposited in situ at the site of each targeted biomolecule.

SpyLigation: Spatiotemporal Control of Protein Function

The innovation is a method to activate protein function near-instantaneously and irreversibly in response to light, accomplished through genetically encoded triggered protein-protein ligation reactions. This method, known as light-activated SpyLigation (LASL), stably re-assembles bioactive proteins from non-functional split fragment pairs following brief exposure to light.

Structure from Motion Reconstruction of Laryngotracheal Surfaces

The solution is the use of an image processing technique, called structure from motion (SfM), to reconstruct 3D surface renderings of the pediatric larynx and trachea from clinical endoscopy videos.

Targeted Protein Degradation in Bacteria Contributes to Antibiotic Efficacy

The solution is a method to develop new antibiotic proteolysis targeting chimeras (PROTACs) that target proteins of interest for degradation in bacteria to counteract antibiotic resistance.

Targeting von Willebrand Factor to Model Disease in Human Pluripotent Stem Cells

The disclosed technology offers a CRISPR-Cas9 generated, isogenic hPSC-EC in-vitro model for studying disease dynamics and therapeutic candidates for VWF-deficient diseases such as Von Willebrand disease (VWD).

TERIS

Transmembrane Protein Pores

This technology offers the computational design of protein pores that can selectively conduct ions and enable the passage of small-molecule fluorophores, offering a new approach to creating transmembrane channels with potential applications in biotechnology and medicine.

Treating Mitochondrial Dysfunction in Heart Failure

This technology targets the root cause of heart failure by employing nicotinamide riboside (NR) to protect mitochondrial function and reduce inflammation, and normalizing MRPP2 levels to improve mitochondrial DNA processing, offering a potential avenue to reverse the course of heart failure.