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Custom Transmembrane β-Barrel Proteins

This technology involves the design of eight-stranded transmembrane β-barrel proteins (TMBs) with no homology to known TMBs, offering potential for a wide range of synthetic biology applications.

TBD
De Novo Designed Protein Binders Targeting TGFβRII, CTLA4, and PD-L1

Novel protein minibinders which bind to convex protein target sites on TGFβRII, CTLA4, and PD-L1 with high affinity and potent biological activity are the solution.

TBD
Deep Learning Approaches for Protein Scaffolding

This technology uses advanced deep learning methods to design proteins with specific functional sites, offering a novel approach to protein design that is both efficient and versatile.

TBD
Homo-Oligomeric Protein Assemblies

The solution is a novel approach to design polypeptides that form cyclic homo-oligomers, offering potential applications in various fields.

TBD
Minibinder-Drug Conjugates Targeting Human EpCAM and PDL1 Receptors for Targeted Cancer Therapy

This technology offers a set of novel polypeptides designed to bind to human EpCAM and PDL1 receptors, offering potential applications in treating cancer, autoimmune diseases, and inflammation.

TBD
Mixed Chirality Peptide Macrocycles with Internal Symmetry

This technology leverages computational design to create mixed chirality peptide macrocycles with internal symmetry, offering a new avenue for therapeutic and nanomaterial design.

TBD
Modulating Prime Editing Efficiency Through Epigenetic Reprogramming

The innovation is a method that involves reprogramming the epigenetic environment in the vicinity of a target site to modulate prime editing efficiency.

TBD
Nanoactuators Based FePd Nanohelices to Initiate Cell Apoptosis

This technology offers a nan-actuator to initiate apoptosis and the removal of cancer cells. The nano-actuators magnetically is propelled to target cells and oscillate for mechanical damage of the cells.

TBD
Novel Nanoparticle Immunogens for Influenza Vaccines

This technology offers a new approach to influenza vaccines using computationally designed nanoparticle immunogens that elicit potent, neutralizing antibodies against influenza viruses.

TBD
Protein Homodimers with Tunable Symmetric Pockets: A Novel Approach to Binding Symmetric Molecules

This technology offers de novo designed protein homodimers with tunable symmetric pockets, enabling the binding of symmetric molecules for diverse applications.

TBD
Systems and Methods for Deep Brain Stimulation Using Kinematic Feedback for Treatment of Movement Disorders

This technology offers the statistical analysis of gait parameters, a motor symptom of Parkinson’s disease. This system conducts deep brain stimulation and adapts its response with the stimulation frequency varying between low (i.e. 60 Hz) and high (>130 Hz) frequencies to improve gait.

TBD
Targeted Protein Degradation in Bacteria Contributes to Antibiotic Efficacy

The solution is a method to develop new antibiotic proteolysis targeting chimeras (PROTACs) that target proteins of interest for degradation in bacteria to counteract antibiotic resistance.

TBD
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