Constitutively Active cGAS for Enhanced Immune Response
This technology involves the design of constitutively active cyclic GMP-AMP synthase (cGAS) mutants that stimulate a robust immune response without the need for DNA binding.
Custom Transmembrane β-Barrel Proteins
This technology involves the design of eight-stranded transmembrane β-barrel proteins (TMBs) with no homology to known TMBs, offering potential for a wide range of synthetic biology applications.
De Novo Designed Protein Binders Targeting TGFβRII, CTLA4, and PD-L1
Novel protein minibinders which bind to convex protein target sites on TGFβRII, CTLA4, and PD-L1 with high affinity and potent biological activity are the solution.
Deep Learning Approaches for Protein Scaffolding
This technology uses advanced deep learning methods to design proteins with specific functional sites, offering a novel approach to protein design that is both efficient and versatile.
Homo-Oligomeric Protein Assemblies
The solution is a novel approach to design polypeptides that form cyclic homo-oligomers, offering potential applications in various fields.
Minibinder-Drug Conjugates Targeting Human EpCAM and PDL1 Receptors for Targeted Cancer Therapy
This technology offers a set of novel polypeptides designed to bind to human EpCAM and PDL1 receptors, offering potential applications in treating cancer, autoimmune diseases, and inflammation.
Mixed Chirality Peptide Macrocycles with Internal Symmetry
This technology leverages computational design to create mixed chirality peptide macrocycles with internal symmetry, offering a new avenue for therapeutic and nanomaterial design.
Modulating Prime Editing Efficiency Through Epigenetic Reprogramming
The innovation is a method that involves reprogramming the epigenetic environment in the vicinity of a target site to modulate prime editing efficiency.
Nanoactuators Based FePd Nanohelices to Initiate Cell Apoptosis
This technology offers a nan-actuator to initiate apoptosis and the removal of cancer cells. The nano-actuators magnetically is propelled to target cells and oscillate for mechanical damage of the cells.
Novel Nanoparticle Immunogens for Influenza Vaccines
This technology offers a new approach to influenza vaccines using computationally designed nanoparticle immunogens that elicit potent, neutralizing antibodies against influenza viruses.
Protein Homodimers with Tunable Symmetric Pockets: A Novel Approach to Binding Symmetric Molecules
This technology offers de novo designed protein homodimers with tunable symmetric pockets, enabling the binding of symmetric molecules for diverse applications.
Systems and Methods for Deep Brain Stimulation Using Kinematic Feedback for Treatment of Movement Disorders
This technology offers the statistical analysis of gait parameters, a motor symptom of Parkinson’s disease. This system conducts deep brain stimulation and adapts its response with the stimulation frequency varying between low (i.e. 60 Hz) and high (>130 Hz) frequencies to improve gait.
Targeted Protein Degradation in Bacteria Contributes to Antibiotic Efficacy
The solution is a method to develop new antibiotic proteolysis targeting chimeras (PROTACs) that target proteins of interest for degradation in bacteria to counteract antibiotic resistance.