Oncology
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High-Throughput Drug Screens on a 3D Tumor-on-a-Chip to Monitor Cancer Cell Viability and Migration
The solution is a three-dimensional human renal cell carcinoma (RCC)-on-a-chip for screening drugs that could be developed as anti-metastasis agents.
Long-Acting Injectable Drug Combinations for Sustained Cancer Therapy and Beyond
These innovations enable the formulation of long-acting injectable drug combinations, including chemotherapies, by transforming short-acting agents into stable, sustained-release nanoparticles or suspensions. The technologies offer a platform approach to improve treatment adherence, reduce dosing frequency, and enhance drug exposure at disease sites.
Metabolite Biomarkers for the Detection of Colorectal Cancer
The technologies offer a simple yet powerful method for identifying serum markers of disease in colon cancer from peripheral blood. These technologies offer high sensitivity and specificity as compared to standard diagnostic methods such as colonoscopy but offer additional utility as they require no in-office clinical procedure. Together, they offer a promising new diagnostic and monitoring tool to support clinical decision making in colon cancer.
Polymer-Based Nanoplatform for mRNA Delivery to Cancer Cells and Stem Cells
A novel nanoparticle system designed for efficient mRNA delivery to various cancer cell types and human induced pluripotent stem cells.